Polynucleotides.
Building blocks derived from salmon DNA, injected to support skin regeneration. For skin quality, the eye area and weakened skin; usually several sessions.
Polynucleotides (PN, 'salmon DNA') explained: origin, assumed mode of action, uses such as the eye area and skin quality, sessions
A closer look.
Polynucleotides are purified DNA fragments obtained from salmon or trout germ cells. They are well tolerated by the human body because DNA building blocks hardly differ between species. Injected into the skin they are meant to stimulate fibroblasts, bind moisture and dampen inflammatory processes.
They are used mainly where the skin is thin or weakened: the eye area, the neck, after sun damage or with acne scars. Unlike skin boosters they provide almost no hydration through water binding but rely on regeneration; that is why the two are sometimes combined. Three sessions two to four weeks apart are usual.
The evidence is younger and thinner than for hyaluronic acid or botulinum toxin; smaller studies show improvements in elasticity and skin texture, large comparative studies are lacking. Side effects match those of other injections; with fish allergy a consultation is needed.
This lexicon entry is general information and does not replace the medical consultation required under German law (§ 630e BGB).
At a glance.
A question about Polynucleotides? Send us a short WhatsApp message – we usually reply the same working day.
Ask via WhatsAppFrequently asked questions.
Is it the same as a skin booster?
No. Skin boosters bind water (hyaluronic acid); polynucleotides are meant to stimulate cell regeneration. Both target skin quality.
Can I have it with a fish allergy?
Please mention it beforehand. The products are highly purified, but the decision is made case by case.
Sources and further reading.
- German Society of Dermatology (DDG)
- DermNet – dermatology reference
- American Academy of Dermatology
- PubMed – biomedical literature database
- § 630e BGB – duty to inform before treatment (German Civil Code)
- DGBT – German Society for Aesthetic Botulinum Toxin Therapy
- AWMF – German clinical practice guidelines
External links open in a new window; their operators are responsible for their content. Medical responsibility for this page: Katayoun Mostaghimi, specialist in general medicine. Last updated: 2026-10-05.
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